Title : Biochemical and pathologic evidence for proteolytic destruction of lung connective tissue in cystic fibrosis.

Pub. Date : 1985 Sep

PMID : 3898942






1 Functional Relationships(s)
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1 Male patients with CF excreted significantly more elastin cross-links (desmosines) in their urine than did control male subjects (3.6 +/- 1.7 micrograms/kg/24 h versus 1.5 +/- 0.6 micrograms/kg/24 h; p less than 0.01), and there was a significant correlation (p less than 0.05) between urine desmosine excretion and the severity of lung disease in the patients with CF as indicated by chest roentgenogram score. Desmosine elastin Homo sapiens