Title : Effect of clonidine on glucose, insulin and glucagon responses to a protein meal in type 2 diabetics.

Pub. Date : 1985 Jun

PMID : 3897355






2 Functional Relationships(s)
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1 The administration of a protein meal caused a significant increase of blood glucose (peak at 60 min), insulin (peak at 90 min) and glucagon (peak at 90 min) levels; the association of clonidine caused an increase of blood glucose (single values and total areas) without changes of insulin and glucagon levels, when compared to those obtained before clonidine treatment. Clonidine insulin Homo sapiens
2 In conclusion, the association of clonidine to a protein meal caused impaired glucose tolerance presumably due to a direct glycogenolytic effect, occurring in the liver on account of an alpha-2 receptor stimulation, insulin and glucagon not being involved in this phenomenon. Clonidine insulin Homo sapiens