Pub. Date : 1985 Jan 10
PMID : 3880742
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | For TMP bound to chicken dihydrofolate reductase we observe an altered binding geometry in which the 2,4-diaminopyrimidine occupies a position in closer proximity (by approximately 1 A) to helix alpha B compared to the pyrimidine position for TMP or methotrexate bound to E. coli dihydrofolate reductase. | pyrimidine | dihydrofolate reductase | Gallus gallus |
| 2 | For TMP bound to chicken dihydrofolate reductase we observe an altered binding geometry in which the 2,4-diaminopyrimidine occupies a position in closer proximity (by approximately 1 A) to helix alpha B compared to the pyrimidine position for TMP or methotrexate bound to E. coli dihydrofolate reductase. | pyrimidine | dihydrofolate reductase | Gallus gallus |
| 3 | One important consequence of this deeper insertion of the pyrimidine into the active site of chicken dihydrofolate reductase is the loss of a potential hydrogen bond that would otherwise form between the carbonyl oxygen of Val-115 and the inhibitor"s 4-amino group. | pyrimidine | dihydrofolate reductase | Gallus gallus |