Pub. Date : 1985 Nov-Dec
PMID : 3832018
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Changes in the rat brain histamine content following metoprine and other histamine-methyltransferase (HMT) inhibitors. | Histamine | histamine N-methyltransferase | Rattus norvegicus |
| 2 | Four compounds: amodiaquine, quinacrine, 1,4-(tele)-methylhistamine and metoprine, which in vitro effectively inhibit histamine N-methyltransferase (HMT) activity, were tested for their effects on histamine (HI) levels in the rat brain and ex vivo HMT activity. | Histamine | histamine N-methyltransferase | Rattus norvegicus |
| 3 | Amodiaquine, quinacrine and 1,4-(tele)-methyl-HI weakly inhibited HMT activity ex vivo and they failed to alter HI levels in the rat brain. | Histamine | histamine N-methyltransferase | Rattus norvegicus |