Title : Urea synthesis from ammonia in periportal and pericentral regions of the liver lobule. Effect of oxygen.

Pub. Date : 1987 Feb 16

PMID : 3816789






1 Functional Relationships(s)
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1 Urea synthesis by the perfused rat liver supplemented with lactate (5 mM), ornithine (2 mM) and methionine sulfoximine (0.15 mM), an inhibitor of glutamine synthetase, was stimulated by stepwise infusion of NH4Cl at doses ranging from 0.24 mM to 3.0 mM. Ammonium Chloride glutamate-ammonia ligase Rattus norvegicus