Title : Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.

Pub. Date : 1979 Sep 10

PMID : 381311






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Mutant Syrian hamster cells resistant to N-(phosphonacetyl)-L-aspartate (PALA), a transition state analog inhibitor of aspartate transcarbamylase, overproduce CAD, a multifunctional protein which catalyzes the first three reactions of de novo UMP biosynthesis. sparfosic acid CAD protein Mesocricetus auratus