Title : Nonquaternary cholinesterase reactivators. 4. Dialkylaminoalkyl thioesters of alpha-keto thiohydroximic acids as reactivators of ethyl methylphosphonyl- and 1,2,2-trimethylpropyl methylphosphonyl-acetylcholinesterase in vitro.

Pub. Date : 1986 Sep

PMID : 3746817






1 Functional Relationships(s)
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1 In this series, varying R substituents on the aryl ring produced compounds with oxime pKa values from 6.8 to 8.0, optimum for an AChE reactivator. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens