Title : Structure-activity relationships of (arylalkyl)imidazole anticonvulsants: comparison of the (fluorenylalkyl)imidazoles with nafimidone and denzimol.

Pub. Date : 1986 Sep

PMID : 3746810






1 Functional Relationships(s)
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1 All active compounds that we tested in this series, as well as denzimol and nafimidone, potentiated hexobarbital-induced sleeping time in mice, probably by imidazole-mediated inhibition of cytochrome P-450. Hexobarbital cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus