Pub. Date : 1986 Jul 28
PMID : 3732509
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Avidin as a probe of the conformational changes induced in pyruvate carboxylase by acetyl-CoA and pyruvate. | Acetyl Coenzyme A | pyruvate carboxylase | Gallus gallus |
| 2 | Similar results were also obtained for chicken liver pyruvate carboxylase despite this enzyme"s almost complete lack of acetyl-CoA-independent activity. | Acetyl Coenzyme A | pyruvate carboxylase | Gallus gallus |
| 3 | Thus, although acetyl-CoA and high concentrations of pyruvate may induce pyruvate carboxylase to adopt a "tight" tetrahedron-like conformation which can interact with avidin to form chains, this structural change alone does not result in an enzymic form that is maximally active. | Acetyl Coenzyme A | pyruvate carboxylase | Gallus gallus |
| 4 | This suggests that the allosteric activation of pyruvate carboxylase by acetyl-CoA is attributable, at least in part to more subtle conformational changes; especially in the case of the chicken enzyme. | Acetyl Coenzyme A | pyruvate carboxylase | Gallus gallus |