Title : Regulation of acyl-CoA:cholesterol acyltransferase activity in normal and atherosclerotic rabbit aortas: role of a cholesterol substrate pool.

Pub. Date : 1986 Jun

PMID : 3720921






8 Functional Relationships(s)
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Protein Name
Organism
1 The higher Vmax is attributable to the saturation of ACAT with not only oleoyl-CoA, but also cholesterol. Cholesterol sterol O-acyltransferase 1 Oryctolagus cuniculus
2 The observation that exogenous cholesterol was necessary for the determination of maximal ACAT activity indicates that under normal conditions the endogenous level of microsomal cholesterol does not saturate ACAT. Cholesterol sterol O-acyltransferase 1 Oryctolagus cuniculus
3 The observation that exogenous cholesterol was necessary for the determination of maximal ACAT activity indicates that under normal conditions the endogenous level of microsomal cholesterol does not saturate ACAT. Cholesterol sterol O-acyltransferase 1 Oryctolagus cuniculus
4 Assay of ACAT in the presence and absence of exogenous cholesterol permits a qualitative assessment of the amount of cholesterol in the cholesterol substrate pool of ACAT. Cholesterol sterol O-acyltransferase 1 Oryctolagus cuniculus
5 Assay of ACAT in the presence and absence of exogenous cholesterol permits a qualitative assessment of the amount of cholesterol in the cholesterol substrate pool of ACAT. Cholesterol sterol O-acyltransferase 1 Oryctolagus cuniculus
6 Assay of ACAT in the presence and absence of exogenous cholesterol permits a qualitative assessment of the amount of cholesterol in the cholesterol substrate pool of ACAT. Cholesterol sterol O-acyltransferase 1 Oryctolagus cuniculus
7 Assay of ACAT in the presence and absence of exogenous cholesterol permits a qualitative assessment of the amount of cholesterol in the cholesterol substrate pool of ACAT. Cholesterol sterol O-acyltransferase 1 Oryctolagus cuniculus
8 Using this approach, it was found that hypercholesterolemia results in the expansion of the cholesterol substrate pool of ACAT. Cholesterol sterol O-acyltransferase 1 Oryctolagus cuniculus