Title : Dependence of benzo[a]pyrene metabolic profile on the concentration of cumene hydroperoxide with uninduced and induced rat liver microsomes.

Pub. Date : 1986 May 1

PMID : 3707619






3 Functional Relationships(s)
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1 These results suggest that CHP-dependent metabolism of BP is selectively mediated by constitutive cytochrome P-450 isozyme(s) and that two forms of BP binding sites exist in cytochrome P-450 isozymes and are responsible for the hydroxylation of BP at C-3 and C-6. Benzo(a)pyrene cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus
2 These results suggest that CHP-dependent metabolism of BP is selectively mediated by constitutive cytochrome P-450 isozyme(s) and that two forms of BP binding sites exist in cytochrome P-450 isozymes and are responsible for the hydroxylation of BP at C-3 and C-6. Benzo(a)pyrene cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus
3 These results suggest that CHP-dependent metabolism of BP is selectively mediated by constitutive cytochrome P-450 isozyme(s) and that two forms of BP binding sites exist in cytochrome P-450 isozymes and are responsible for the hydroxylation of BP at C-3 and C-6. Benzo(a)pyrene cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus