Pub. Date : 1986 May 1
PMID : 3707613
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of propiolaldehyde and other metabolites in the pargyline inhibition of rat liver aldehyde dehydrogenase. | Pargyline | aldehyde dehydrogenase 3 family, member A1 | Rattus norvegicus |
| 2 | Other putative metabolites of pargyline, namely benzylamine and propargylamine, inhibited AlDH in vivo, albeit to a lesser degree than pargyline, but neither of these amines inhibited AlDH directly. | Pargyline | aldehyde dehydrogenase 3 family, member A1 | Rattus norvegicus |
| 3 | From these studies, we conclude that propiolaldehyde was the primary metabolite responsible for the pargyline inhibition of AlDH in vivo; however, certain amine metabolites may have contributed to a lesser degree by conversion to yet unknown inhibitory forms. | Pargyline | aldehyde dehydrogenase 3 family, member A1 | Rattus norvegicus |