Title : Effects of tumor necrosis factor on bone formation in vitro.

Pub. Date : 1987 Nov

PMID : 3665833






1 Functional Relationships(s)
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1 TNF alpha at 100-100,000 U/ml stimulated [3H]thymidine incorporation into DNA, an effect that appeared after 24 h of treatment and lasted 96 h. Transient (24-h) treatment with TNF alpha increased [3H]proline incorporation into type I collagen 24-72 h after the factor was removed; this effect was DNA synthesis dependent and blocked by hydroxyurea. Thymidine tumor necrosis factor-like Rattus norvegicus