Pub. Date : 1986 May
PMID : 3641693
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A comparison of the effects of danazol and gestrinone on testosterone binding to sex hormone binding globulin in vitro and in vivo. | Danazol | sex hormone binding globulin | Homo sapiens |
| 2 | The mean SHBG binding capacity in patients treated with danazol (400 mg/d, n = 7) and gestrinone (5 mg/week, n = 7) fell from 66.9 and 56.4 nmol/l to 36.1 and 28.1 nmol/l, after 1 week"s treatment and to 11.1 and 7.1 nmol/l after 4 weeks respectively. | Danazol | sex hormone binding globulin | Homo sapiens |
| 3 | Despite the similarity between the falls in SHBG binding capacity there was a significantly greater increase in % free testosterone in plasma samples from patients treated with danazol than in those from patients treated with gestrinone at 1 week. | Danazol | sex hormone binding globulin | Homo sapiens |
| 4 | Experiments in vitro suggest that this was largely due to ethisterone (a major metabolite of danazol) competing with testosterone for SHBG binding sites. | Danazol | sex hormone binding globulin | Homo sapiens |