Title : Effect of leucine on the pyridine nucleotide contents of islets and on the insulin released--interactions in vitro with methylene blue, thiol oxidants, and p-chloromercuribenzoate.

Pub. Date : 1979 Jun

PMID : 36318






4 Functional Relationships(s)
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1 Our data suggest that the insulin-releasing action of leucine depends on the islets" NADPH and reduced glutathione (GSH); in addition, leucine may contribute to insulin secretion by increasing the islet NADPH:NADP ratio and the NADH:NAD ratio. NADP insulin Homo sapiens
2 Our data suggest that the insulin-releasing action of leucine depends on the islets" NADPH and reduced glutathione (GSH); in addition, leucine may contribute to insulin secretion by increasing the islet NADPH:NADP ratio and the NADH:NAD ratio. NADP insulin Homo sapiens
3 Our data suggest that the insulin-releasing action of leucine depends on the islets" NADPH and reduced glutathione (GSH); in addition, leucine may contribute to insulin secretion by increasing the islet NADPH:NADP ratio and the NADH:NAD ratio. NADP insulin Homo sapiens
4 From the data, we assume that the observed increase of NADPH may lead via GSH to an increase in the number of such thiol groups in the beta-cell membrane, which are believed to be related to stimulation of insulin release and, thus, to increase the sensitivity of the beta-cell to stimulation by glucose and/or leucine. NADP insulin Homo sapiens