Title : Hepatic metabolism of tolbutamide: characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition.

Pub. Date : 1987 Jun

PMID : 3598900






2 Functional Relationships(s)
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1 Hepatic metabolism of tolbutamide: characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition. Tolbutamide cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 In vitro investigations suggest the same human liver cytochrome P-450 that catalyzes S-mephenytoin 4-hydroxylation, P-450MP, is responsible for methyl hydroxylation of the oral hypoglycemic agent tolbutamide. Tolbutamide cytochrome P450 family 4 subfamily F member 3 Homo sapiens