Title : Differential induction of transcription of c-myc and c-fos proto-oncogenes by 12-O-tetradecanoylphorbol-13-acetate in mortal and immortal human urothelial cells.

Pub. Date : 1987 Jun

PMID : 3597558






4 Functional Relationships(s)
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1 Differential induction of transcription of c-myc and c-fos proto-oncogenes by 12-O-tetradecanoylphorbol-13-acetate in mortal and immortal human urothelial cells. Tetradecanoylphorbol Acetate MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 A single treatment with TPA (1 microgram/ml) increased the transcription of c-fos and c-myc proto-oncogenes at least 20-fold in the mortal cell line HU 1752. Tetradecanoylphorbol Acetate MYC proto-oncogene, bHLH transcription factor Homo sapiens
3 When immortalized cell lines were treated with TPA a similar rapid and transient morphological response was observed, but the TPA treatment only increased the level of c-fos mRNA, suggesting that the normal regulation of c-myc transcription is altered in immortalized cells irrespective of their tumorigenic properties. Tetradecanoylphorbol Acetate MYC proto-oncogene, bHLH transcription factor Homo sapiens
4 When immortalized cell lines were treated with TPA a similar rapid and transient morphological response was observed, but the TPA treatment only increased the level of c-fos mRNA, suggesting that the normal regulation of c-myc transcription is altered in immortalized cells irrespective of their tumorigenic properties. Tetradecanoylphorbol Acetate MYC proto-oncogene, bHLH transcription factor Homo sapiens