Pub. Date : 1987 Feb 1
PMID : 3593215
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study investigated the effects of sub-threshold concentrations of adrenaline (0.1-1 microM) on vasopressin (10 nM-1 microM)-induced platelet aggregation, ATP secretion, elevation of cytosolic free Ca2+ concentration ([Ca2+]i) and hydrolysis of inositol phospholipids, monitored as [32P]phosphatidic acid formation. | Epinephrine | arginine vasopressin | Homo sapiens |
| 2 | Potentiation of vasopressin-induced aggregation and ATP secretion by adrenaline was accompanied by enhanced elevation of [Ca2+]i and [32P]phosphatidic acid formation. | Epinephrine | arginine vasopressin | Homo sapiens |
| 3 | The stimulatory effects of adrenaline on vasopressin-induced platelet activation were mimicked by the combination of the Ca2+ ionophore, ionomycin, and the protein kinase C activator, phorbol 12-myristate 13-acetate, but not by either of these agents alone. | Epinephrine | arginine vasopressin | Homo sapiens |
| 4 | These results suggest that the potentiation of vasopressin-induced platelet activation by adrenaline is mediated via enhancement of inositol phospholipid hydrolysis and elevation of [Ca2+]i. | Epinephrine | arginine vasopressin | Homo sapiens |