Title : Characterization of ciprofibrate and clofibric acid as peroxisomal proliferators in primary cultures of rat hepatocytes.

Pub. Date : 1987 May-Jun

PMID : 3570161






2 Functional Relationships(s)
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1 In cultured hepatocytes, ciprofibrate was about 30-fold more active than clofibric acid for the stimulation of carnitine acetyltransferase, laurate hydroxylase and fatty acylCoA oxidase activities. ciprofibrate carnitine O-acetyltransferase Rattus norvegicus
2 The maximal drug-induced increases in carnitine acetyltransferase activity were not additive, and the induction of carnitine acetyltransferase by ciprofibrate was blocked by addition (1 micrograms per ml) of cycloheximide or actinomycin D. ciprofibrate carnitine O-acetyltransferase Rattus norvegicus