Title : Phase I/II trial of interferon-beta-serine in patients with renal cell carcinoma: immunological and biological effects.

Pub. Date : 1987 May 1

PMID : 3567933






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Interferon-beta-serine (IFN-beta ser) is a recombinant genetically altered interferon with extensive in vitro antiproliferative, antiviral, and immunological effects. Serine interferon beta 1 Homo sapiens
2 Interferon-beta-serine (IFN-beta ser) is a recombinant genetically altered interferon with extensive in vitro antiproliferative, antiviral, and immunological effects. Serine interferon beta 1 Homo sapiens
3 IFN-beta ser was given twice weekly (Monday/Thursday) by a 4-h i.v. Serine interferon beta 1 Homo sapiens
4 Preliminary studies with normal donor cells demonstrated that IFN-beta ser in vitro enhanced activity in a mononuclear-MBL-2 growth inhibition, NK-cell, and monocyte antibody-dependent cellular cytotoxicity assay. Serine interferon beta 1 Homo sapiens
5 In general changes in these assays were observed at low levels of IFN-beta ser, increased at 4-48 h, then returned toward base line. Serine interferon beta 1 Homo sapiens
6 We conclude that IFN-beta ser is an active biological agent in vitro and significantly modulated the biological responses in patients with renal cell carcinoma. Serine interferon beta 1 Homo sapiens