Title : Prothrombin Tokushima, a replacement of arginine-418 by tryptophan that impairs the fibrinogen clotting activity of derived thrombin Tokushima.

Pub. Date : 1987 Feb 24

PMID : 3567158






2 Functional Relationships(s)
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Protein Name
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1 Amino acid sequence analysis of a peptide isolated from a lysyl endopeptidase digest of the abnormal thrombin indicated that Arg-418 (equivalent to Asn-101 in the chymotrypsin numbering system) had been replaced by Trp. Tryptophan coagulation factor II, thrombin Homo sapiens
2 The Arg----Trp replacement found in the thrombin portion of prothrombin Tokushima appears to reduce its interaction with various substrates including fibrinogen and platelet receptors and accounts for the recurrent bleeding episode observed in the propositus. Tryptophan coagulation factor II, thrombin Homo sapiens