Title : The pathogenesis of, and pharmacological treatment for, Canavan disease.

Pub. Date : 2022 May 27

PMID : 35636725






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 ASPA is highly expressed in oligodendrocytes and catalyzes the cleavage of N-acetylaspartate (NAA) to produce aspartate and acetate. N-acetylaspartate aspartoacylase Homo sapiens
2 ASPA is highly expressed in oligodendrocytes and catalyzes the cleavage of N-acetylaspartate (NAA) to produce aspartate and acetate. N-acetylaspartate aspartoacylase Homo sapiens
3 In this review ,we examine the pathologies and clinical presentation in CD, the metabolism and transportation of NAA in the brain, and the hypothetical mechanisms whereby ASPA deficiency results in dysmyelination and a failure of normal brain development. N-acetylaspartate aspartoacylase Homo sapiens