Pub. Date : 2022 Apr 19
PMID : 35631320
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of Nrf2/HO-1 Antioxidant Pathway by Heme Attenuates Calcification of Human Lens Epithelial Cells. | Heme | heme oxygenase 1 | Homo sapiens |
| 2 | We used heme to activate Nrf2, which strongly upregulated the expression of Nrf2 and heme oxygenase-1 (HO-1). | Heme | heme oxygenase 1 | Homo sapiens |
| 3 | We used heme to activate Nrf2, which strongly upregulated the expression of Nrf2 and heme oxygenase-1 (HO-1). | Heme | heme oxygenase 1 | Homo sapiens |
| 4 | Anti-calcification effect of heme was lost when the transcriptional activity of Nrf2 or the enzyme activity of HO-1 was blocked with pharmacological inhibitors. | Heme | heme oxygenase 1 | Homo sapiens |
| 5 | Among products of HO-1 catalyzed heme degradation iron mimicked the anti-calcification effect of heme. | Heme | heme oxygenase 1 | Homo sapiens |
| 6 | Among products of HO-1 catalyzed heme degradation iron mimicked the anti-calcification effect of heme. | Heme | heme oxygenase 1 | Homo sapiens |
| 7 | We concluded that heme-induced upregulation of the Nrf2/HO-1 system inhibits HuLECs calcification through the liberation of heme iron. | Heme | heme oxygenase 1 | Homo sapiens |
| 8 | We concluded that heme-induced upregulation of the Nrf2/HO-1 system inhibits HuLECs calcification through the liberation of heme iron. | Heme | heme oxygenase 1 | Homo sapiens |