Title : Design, Synthesis, Bioactivity Evaluation, Crystal Structures, and In Silico Studies of New α-Amino Amide Derivatives as Potential Histone Deacetylase 6 Inhibitors.

Pub. Date : 2022 May 22

PMID : 35630812






1 Functional Relationships(s)
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1 The interaction pattern analysis showed that the alpha-amino amide moiety of 7a coordinated with the zinc ion of HDAC6 in a bidentate chelate manner, which is similar to the chelation pattern of hydroxamic acid. Hydroxamic Acids histone deacetylase 6 Homo sapiens