Title : Investigating the molecular mechanisms of glyoxal-induced cytotoxicity in human embryonic kidney cells: Insights from network toxicology and cell biology experiments.

Pub. Date : 2022 May 27

PMID : 35621379






3 Functional Relationships(s)
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Protein Name
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1 Network toxicology results showed that oxidative stress and advanced glycation end products (AGEs)/RAGE signaling pathways played a crucial role in glyoxal toxicity. Glyoxal MOK protein kinase Homo sapiens
2 Glyoxal activated the AGEs-RAGE signaling pathway, caused the increase of cellular ROS, and activated the p38MAPK and JNK signaling pathways, causing cellular oxidative stress. Glyoxal MOK protein kinase Homo sapiens
3 The results that obtained in cell biology were consistent with network toxicology, which corroborated each other and together indicated that glyoxal induced HEK293 cells damage via the process of oxidative stress, the AGEs-RAGE pathway, and their associated signaling pathways. Glyoxal MOK protein kinase Homo sapiens