Pub. Date : 2022
PMID : 35617303
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | For rapidly multiplying malignancies, this has made TOP2alpha/170 an important target for etoposide and other clinically active anticancer drugs. | Etoposide | DNA topoisomerase II alpha | Homo sapiens |
| 2 | Our laboratory recently demonstrated reduced levels of TOP2alpha/170 and overexpression of a C-terminal truncated 90-kDa isoform, TOP2alpha/90, due to intronic polyadenylation (IPA; within intron 19) in an acquired etoposide-resistant K562 clonal cell line, K/VP.5. | Etoposide | DNA topoisomerase II alpha | Homo sapiens |
| 3 | We previously reported that this isoform heterodimerized with TOP2alpha/170 and was a determinant of acquired resistance to etoposide. | Etoposide | DNA topoisomerase II alpha | Homo sapiens |
| 4 | TOP2alpha/170 mRNA/protein expression levels were attenuated in the TOP2alpha gene-edited clones which resulted in resistance to etoposide as assessed by reduced etoposide-induced DNA damage (gammaH2AX, Comet assays) and growth inhibition. | Etoposide | DNA topoisomerase II alpha | Homo sapiens |
| 5 | TOP2alpha/170 mRNA/protein expression levels were attenuated in the TOP2alpha gene-edited clones which resulted in resistance to etoposide as assessed by reduced etoposide-induced DNA damage (gammaH2AX, Comet assays) and growth inhibition. | Etoposide | DNA topoisomerase II alpha | Homo sapiens |
| 6 | TOP2alpha/170 mRNA/protein expression levels were attenuated in the TOP2alpha gene-edited clones which resulted in resistance to etoposide as assessed by reduced etoposide-induced DNA damage (gammaH2AX, Comet assays) and growth inhibition. | Etoposide | DNA topoisomerase II alpha | Homo sapiens |
| 7 | TOP2alpha/170 mRNA/protein expression levels were attenuated in the TOP2alpha gene-edited clones which resulted in resistance to etoposide as assessed by reduced etoposide-induced DNA damage (gammaH2AX, Comet assays) and growth inhibition. | Etoposide | DNA topoisomerase II alpha | Homo sapiens |
| 8 | Forced expression of TOP2alpha/90 in the gene-edited K562 cells further decreased etoposide-induced DNA damage in support of a dominant negative role for this truncated isoform. | Etoposide | DNA topoisomerase II alpha | Homo sapiens |