Title : Modulating insulin signaling and trafficking at the blood-brain barrier endothelium using lipid based nanoemulsions.

Pub. Date : 2022 Jun 25

PMID : 35605891






6 Functional Relationships(s)
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1 Moreover, western blot and flow cytometry analysis showed that SNEs containing polyunsaturated fatty acids (PUFAs) increased phospo-AKT (p-AKT) expression, a marker for the stimulation of metabolic arm of the insulin signaling, and insulin uptake in human cerebral microvascular endothelial cell (hCMEC/D3) monolayers. Fatty Acids, Unsaturated insulin Homo sapiens
2 Moreover, western blot and flow cytometry analysis showed that SNEs containing polyunsaturated fatty acids (PUFAs) increased phospo-AKT (p-AKT) expression, a marker for the stimulation of metabolic arm of the insulin signaling, and insulin uptake in human cerebral microvascular endothelial cell (hCMEC/D3) monolayers. Fatty Acids, Unsaturated insulin Homo sapiens
3 Moreover, western blot and flow cytometry analysis showed that SNEs containing polyunsaturated fatty acids (PUFAs) increased phospo-AKT (p-AKT) expression, a marker for the stimulation of metabolic arm of the insulin signaling, and insulin uptake in human cerebral microvascular endothelial cell (hCMEC/D3) monolayers. Fatty Acids, Unsaturated insulin Homo sapiens
4 Moreover, western blot and flow cytometry analysis showed that SNEs containing polyunsaturated fatty acids (PUFAs) increased phospo-AKT (p-AKT) expression, a marker for the stimulation of metabolic arm of the insulin signaling, and insulin uptake in human cerebral microvascular endothelial cell (hCMEC/D3) monolayers. Fatty Acids, Unsaturated insulin Homo sapiens
5 These findings provided direct evidence that SNEs containing PUFAs can upregulate insulin-pAKT pathway, facilitate insulin trafficking at the BBB, and thereby address cerebrovascular dysfunction in metabolic and neurodegenerative diseases. Fatty Acids, Unsaturated insulin Homo sapiens
6 These findings provided direct evidence that SNEs containing PUFAs can upregulate insulin-pAKT pathway, facilitate insulin trafficking at the BBB, and thereby address cerebrovascular dysfunction in metabolic and neurodegenerative diseases. Fatty Acids, Unsaturated insulin Homo sapiens