Pub. Date : 2022 Jul
PMID : 35605433
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The results showed that DMF suppressed the activation of NLRP3 inflammasome activation in lipopolysaccharide-primed murine bone marrow-derived macrophages upon ATP or nigericin treatment, as evidenced by reduced cleavage of pro-caspase-1, release of mature interleukin-1beta (IL-1beta) and generation of gasdermin D N-terminal fragment (GSDMD-NT). | Dimethyl Fumarate | gasdermin D | Mus musculus |
| 2 | The results showed that DMF suppressed the activation of NLRP3 inflammasome activation in lipopolysaccharide-primed murine bone marrow-derived macrophages upon ATP or nigericin treatment, as evidenced by reduced cleavage of pro-caspase-1, release of mature interleukin-1beta (IL-1beta) and generation of gasdermin D N-terminal fragment (GSDMD-NT). | Dimethyl Fumarate | gasdermin D | Mus musculus |
| 3 | Consistent with reduced generation of GSDMD-NT, ATP or nigericin-induced pyroptosis was markedly suppressed by DMF. | Dimethyl Fumarate | gasdermin D | Mus musculus |
| 4 | Importantly, DMF decreased serum levels of inflammatory cytokines and ameliorated liver injury in Con A-induced AIH of mice, concomitant with reduced the generation of caspase-1p10 and GSDMD-NT and alleviating mitochondrial aggregation in the liver. | Dimethyl Fumarate | gasdermin D | Mus musculus |