Title : Inhibition of IRAK4 dysregulates SARS-CoV-2 spike protein-induced macrophage inflammatory and glycolytic reprogramming.

Pub. Date : 2022 May 19

PMID : 35588018






1 Functional Relationships(s)
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1 This metabolic adaptation promoted by IRAK4i in Spike protein-activated MThetas was shown to be in part through constraining PFKBF3, HIF1alpha, cMYC, LDHA, lactate expression, and reversal of citrate and succinate buildup. Lactic Acid surface glycoprotein Severe acute respiratory syndrome coronavirus 2