Title : Single-Molecule Sensing of an Anticancer Therapeutic Protein-Protein Interaction Using the Chemically Modified OmpG Nanopore.

Pub. Date : 2022 May 31

PMID : 35583342






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Here, we characterized the interaction between Bcl-xL and Bak-BH3 as well as its inhibition by a small-molecule inhibitor using click chemistry-based Bak-BH3 peptide-conjugated OmpG nanopores. BH 3 BCL2 like 1 Homo sapiens
2 Here, we characterized the interaction between Bcl-xL and Bak-BH3 as well as its inhibition by a small-molecule inhibitor using click chemistry-based Bak-BH3 peptide-conjugated OmpG nanopores. BH 3 BCL2 like 1 Homo sapiens
3 The binding of Bcl-xL to Bak-BH3 generated characteristic gating signals involving significant changes in the amplitudes of noise and gating parameters such as gating frequency, open probability, and durations of open and closed states. BH 3 BCL2 like 1 Homo sapiens