Title : GRK5 is an essential co-repressor of the cardiac mineralocorticoid receptor and is selectively induced by finerenone.

Pub. Date : 2022 Apr 26

PMID : 35582468






2 Functional Relationships(s)
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1 AIM: To investigate potential differences between finerenone and eplerenone at engaging GRK5-dependent cardiac MR phosphorylation and subsequent blockade. Eplerenone nuclear receptor subfamily 3 group C member 2 Homo sapiens
2 Unlike eplerenone, finerenone alone potently and efficiently suppresses cardiac MR transcriptional activity, thus displaying inverse agonism. Eplerenone nuclear receptor subfamily 3 group C member 2 Homo sapiens