Title : The antidepressant imipramine inhibits breast cancer growth by targeting estrogen receptor signaling and DNA repair events.

Pub. Date : 2022 Aug 1

PMID : 35568265






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1 Our studies in preclinical mouse models and ex vivo explants from breast cancer patients show that imipramine sensitizes TNBC to the PARP inhibitor olaparib and endocrine resistant ER + breast cancer to anti-estrogens. olaparib collagen type XI alpha 2 chain Homo sapiens