Title : Short-Term Autophagy Preconditioning Upregulates the Expression of COX2 and PGE2 and Alters the Immune Phenotype of Human Adipose-Derived Stem Cells In Vitro.

Pub. Date : 2022 Apr 19

PMID : 35563682






3 Functional Relationships(s)
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1 Following preconditioning, both Rapa and 3-MA-treated hASCs demonstrated preservation of stemness, as well as upregulated transcription of cyclooxygenase-2 (COX2) and interleukin-6 (IL-6). Sirolimus interleukin 6 Homo sapiens
2 Following preconditioning, both Rapa and 3-MA-treated hASCs demonstrated preservation of stemness, as well as upregulated transcription of cyclooxygenase-2 (COX2) and interleukin-6 (IL-6). Sirolimus interleukin 6 Homo sapiens
3 Rapa-pretreated cells, but not 3-MA-pretreated cells, further amplified COX2 and IL-6 transcripts following IFNgamma exposure, and both groups upregulated secretion of prostaglandin-E2 (PGE2), the enzymatic product of COX2. Sirolimus interleukin 6 Homo sapiens