Title : Sulforaphane Suppresses the Nicotine-Induced Expression of the Matrix Metalloproteinase-9 via Inhibiting ROS-Mediated AP-1 and NF-κB Signaling in Human Gastric Cancer Cells.

Pub. Date : 2022 May 5

PMID : 35563563






2 Functional Relationships(s)
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1 ROS/MAPK (p38 MAPK, Erk1/2) and ROS functioned as upstream signaling of AP-1 and NF-kappaB, respectively. Reactive Oxygen Species mitogen-activated protein kinase 3 Homo sapiens
2 Sulforaphane suppresses the nicotine-induced MMP-9 by inhibiting ROS-mediated MAPK (p38 MAPK, Erk1/2)/AP-1 and ROS-mediated NF-kappaB signaling axes, which in turn inhibit cell invasion in human gastric cancer AGS cells. Reactive Oxygen Species mitogen-activated protein kinase 3 Homo sapiens