Title : Specific Amino Acid Substitutions in OXA-51-Type β-Lactamase Enhance Catalytic Activity to a Level Comparable to Carbapenemase OXA-23 and OXA-24/40.

Pub. Date : 2022 Apr 19

PMID : 35562886






1 Functional Relationships(s)
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1 The combination of W222G and I129L substitutions exhibited an extremely strong catalytic enhancement effect in OXA-66, resulting in higher activity than OXA-23 and OXA-24/40 against carbapenems. 2-phenyloxazolone class D beta-lactamase OXA-23 Acinetobacter baumannii