Title : Hormone-controlled cooperative binding of transcription factors drives synergistic induction of fasting-regulated genes.

Pub. Date : 2022 Jun 10

PMID : 35556130






1 Functional Relationships(s)
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1 The cooperative mechanism driving synergistic gene expression is based on "assisted loading" whereby a glucagon-activated TF (cAMP responsive element binding protein; CREB) leads to enhancer activation which facilitates binding of the glucocorticoid receptor (GR) upon glucocorticoid stimulation. Cyclic AMP cAMP responsive element binding protein 1 Mus musculus