Pub. Date : 2022
PMID : 35548336
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histamine Potentiates SARS-CoV-2 Spike Protein Entry Into Endothelial Cells. | Histamine | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 2 | Investigating the effects of recombinant SARS-CoV-2 spike protein S1 Receptor-Binding Domain (Spike) on ACE2 expression in cultured human coronary artery endothelial cells, we found that the presence of histamine potentiated spike-mediated ACE2 internalization into endothelial cells. | Histamine | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 3 | Investigating the effects of recombinant SARS-CoV-2 spike protein S1 Receptor-Binding Domain (Spike) on ACE2 expression in cultured human coronary artery endothelial cells, we found that the presence of histamine potentiated spike-mediated ACE2 internalization into endothelial cells. | Histamine | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 4 | Together, these results indicate that histamine and histamine receptor signaling is likely essential for spike protein to induce ACE2 internalization in endothelial cells and cause endothelial dysfunction and that this effect can be blocked by the H2R blocker, famotidine. | Histamine | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 5 | Together, these results indicate that histamine and histamine receptor signaling is likely essential for spike protein to induce ACE2 internalization in endothelial cells and cause endothelial dysfunction and that this effect can be blocked by the H2R blocker, famotidine. | Histamine | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |