Pub. Date : 2022 May 11
PMID : 35545425
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We analyzed whether 5HT input is implicated in the enhanced PVN TRH transcription that anorectic rats exhibit, given that 5HT increases TRH expression and release when studied in vitro By using mHypoA-2/30 hypothalamic cell cultures, we found that 5HT stimulated TRH mRNA, pCREB and pERK1/2 levels. | Serotonin | thyrotropin releasing hormone | Rattus norvegicus |
| 2 | Our results support that the anorectic effects of serotonin are mediated by PVN TRH in this model.Significance statementInteraction between brain peptides and neurotransmitters" pathways regulates feeding behavior, but when altered it could lead to the development of eating disorders, such as anorexia. | Serotonin | thyrotropin releasing hormone | Rattus norvegicus |
| 3 | The role of neurotransmitters in that alteration is unknown, and since serotonin inhibits feeding and has receptors in PVN, we analyzed its participation in increasing TRH expression and reducing feeding in anorectic rats. | Serotonin | thyrotropin releasing hormone | Rattus norvegicus |
| 4 | By antagonizing PVN serotonin receptors in anorectic rats, we identify decreased TRH expression and increased feeding, suggesting that the anorectic effects of serotonin are mediated by PVN TRH. | Serotonin | thyrotropin releasing hormone | Rattus norvegicus |
| 5 | By antagonizing PVN serotonin receptors in anorectic rats, we identify decreased TRH expression and increased feeding, suggesting that the anorectic effects of serotonin are mediated by PVN TRH. | Serotonin | thyrotropin releasing hormone | Rattus norvegicus |
| 6 | By antagonizing PVN serotonin receptors in anorectic rats, we identify decreased TRH expression and increased feeding, suggesting that the anorectic effects of serotonin are mediated by PVN TRH. | Serotonin | thyrotropin releasing hormone | Rattus norvegicus |
| 7 | By antagonizing PVN serotonin receptors in anorectic rats, we identify decreased TRH expression and increased feeding, suggesting that the anorectic effects of serotonin are mediated by PVN TRH. | Serotonin | thyrotropin releasing hormone | Rattus norvegicus |