Title : The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62.

Pub. Date : 2022 May 10

PMID : 35545049






2 Functional Relationships(s)
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1 PARP inhibitors, such as olaparib, mimick lactate in the reduction of stromal p62 levels, as well as the subsequent stromal activation both in vitro and in vivo, which suggests that therapies using olaparib would benefit from strategies aimed at inhibiting CAF activity. olaparib nucleoporin 62 Homo sapiens
2 PARP inhibitors, such as olaparib, mimick lactate in the reduction of stromal p62 levels, as well as the subsequent stromal activation both in vitro and in vivo, which suggests that therapies using olaparib would benefit from strategies aimed at inhibiting CAF activity. olaparib nucleoporin 62 Homo sapiens