Title : Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells.

Pub. Date : 2022 May 10

PMID : 35538534






3 Functional Relationships(s)
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1 Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells. lysophosphatidic acid thymoma viral proto-oncogene 1 Mus musculus
2 To identify signaling molecules regulating Smurf2 expression by LPA, pharmacological inhibitors such as A6370 (Akt1/2 kinase inhibitor) and Ly 294002 (PI3K inhibitor) were used. lysophosphatidic acid thymoma viral proto-oncogene 1 Mus musculus
3 CONCLUSION: Collectively, the results demonstrated that the ROS/Akt-dependent downregulation of Smurf2 and the subsequent increase in ChREBP expression might be one of the mechanisms by which LPA induces mesangial cell fibrosis in DN. lysophosphatidic acid thymoma viral proto-oncogene 1 Mus musculus