Title : [Tetrahydropalmatine alleviated diabetic neuropathic pain by inhibiting activation of microglia via p38 MAPK signaling pathway].

Pub. Date : 2022 May

PMID : 35531701






1 Functional Relationships(s)
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1 Meanwhile, THP promoted the change of LPS-induced BV2 microglia from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype, suppressed the activation of the p38 MAPK signaling pathway, decreased the expression levels of inflammatory factors NO, IL-1beta, IL-6, and TNF-alpha, and increased the expression level of anti-inflammatory factor IL-10. pirarubicin tumor necrosis factor Rattus norvegicus