Title : RNA Demethylase ALKBH5 Prevents Lung Cancer Progression by Regulating EMT and Stemness via Regulating p53.

Pub. Date : 2022

PMID : 35530319






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Knockdown of p53 or inhibition of p53"s transcriptional activity by addition of its specific inhibitor PFT-alpha decreased expression of ALKBH5 and CSCs" malignancies, including proliferation, invasion, and tumor formation ability, indicating that p53 may partially regulate CSC"s malignancies via ALKBH5. pifithrin tumor protein p53 Homo sapiens
2 Knockdown of p53 or inhibition of p53"s transcriptional activity by addition of its specific inhibitor PFT-alpha decreased expression of ALKBH5 and CSCs" malignancies, including proliferation, invasion, and tumor formation ability, indicating that p53 may partially regulate CSC"s malignancies via ALKBH5. pifithrin tumor protein p53 Homo sapiens
3 Knockdown of p53 or inhibition of p53"s transcriptional activity by addition of its specific inhibitor PFT-alpha decreased expression of ALKBH5 and CSCs" malignancies, including proliferation, invasion, and tumor formation ability, indicating that p53 may partially regulate CSC"s malignancies via ALKBH5. pifithrin tumor protein p53 Homo sapiens