Pub. Date : 2022 Jun 15
PMID : 35526766
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Being the first marketed drug for AD, tacrine reversibly inhibits AChE and thereby slows the breakdown of the chemical messenger acetylcholine (ACh) in the brain. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | However, the atomic level of interactions of tacrine towards human AChE (hAChE) is unknown for years. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | However, the atomic level of interactions of tacrine towards human AChE (hAChE) is unknown for years. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | Hence, in the current study, we report the X-ray structure of hAChE-tacrine complex at 2.85 A resolution. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | The conformational heterogeneity of tacrine within the electron density was addressed with the help of molecular mechanics assisted methods and the low-energy ligand configuration is reported, which provides a mechanistic explanation for the high binding affinity of tacrine towards AChE. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 6 | The conformational heterogeneity of tacrine within the electron density was addressed with the help of molecular mechanics assisted methods and the low-energy ligand configuration is reported, which provides a mechanistic explanation for the high binding affinity of tacrine towards AChE. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |