Title : Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents.

Pub. Date : 2022 Aug 5

PMID : 35526478






1 Functional Relationships(s)
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1 Mono-fluorinated oximes showed comparable reactivation to non-halogenated (except asoxime) and mono-chlorinated oximes in case of AChE inhibited by sarin, cyclosarin, VX, and tabun, but were less efficient than di-chlorinated ones. tabun acetylcholinesterase (Cartwright blood group) Homo sapiens