Title : A two-directional vibrational probe reveals different electric field orientations in solution and an enzyme active site.

Pub. Date : 2022 May 5

PMID : 35513508






1 Functional Relationships(s)
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1 In contrast, we find that for an active-site aldehyde inhibitor of liver alcohol dehydrogenase, the electric field orientation deviates markedly from that found in solvents, which provides direct evidence for the fundamental difference between the electrostatic environment of solvents and that of a preorganized enzyme active site. Aldehydes aldo-keto reductase family 1 member A1 Homo sapiens