Title : Prediction of Carboxylesterase 1 (CES1)-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models.

Pub. Date : 2022 May 5

PMID : 35512806






4 Functional Relationships(s)
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1 Prediction of Carboxylesterase 1 (CES1)-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models. Cannabinoids carboxylesterase 1 Homo sapiens
2 Prediction of Carboxylesterase 1 (CES1)-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models. Cannabinoids carboxylesterase 1 Homo sapiens
3 Oral MPH undergoes extensive pre-systemic metabolism by carboxylesterase 1 (CES1), a hepatic enzyme which can be inhibited by two prominent cannabinoids, 9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Cannabinoids carboxylesterase 1 Homo sapiens
4 Oral MPH undergoes extensive pre-systemic metabolism by carboxylesterase 1 (CES1), a hepatic enzyme which can be inhibited by two prominent cannabinoids, 9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Cannabinoids carboxylesterase 1 Homo sapiens