Title : Ambient particulate matter exposure plus a high-fat diet exacerbate renal injury by activating the NLRP3 inflammasome and TGF-β1/Smad2 signaling pathway in mice.

Pub. Date : 2022 Jun 15

PMID : 35512472






1 Functional Relationships(s)
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1 Moreover, ambient PM exposure activated the nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome and increased the inflammatory response, as indicated by the increases in interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha in the serum and kidney, as well as the upregulation of specific renal fibrosis-related markers (transforming growth factor-beta1 and p-Smad2) in the kidney tissues of mice. Leucine NLR family, pyrin domain containing 3 Mus musculus