Pub. Date : 2022 Apr
PMID : 35510237
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nitroglycerin-induced downregulation of AKT- and ERK1/2-mediated radiation-sensitive 52 expression to enhance pemetrexed-induced cytotoxicity in human lung cancer cells. | Nitroglycerin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In 2 NSCLC cell lines (i.e. lung squamous cell carcinoma H520 and lung adenocarcinoma H1975 cells), NTG reduced Rad52 expression; in addition, decreased phospho-AKT and phospho-ERK1/2 protein levels were observed. | Nitroglycerin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Enhancement of AKT or ERK1/2 activity through transfection with a constitutively active AKT (AKT-CA) vector or constitutively active mitogen-activated protein kinase kinase 1 (MKK1-CA) vector increased the Rad52 protein level and cell survival, which were suppressed by NTG. | Nitroglycerin | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Enhancement of AKT or ERK1/2 activity through transfection with a constitutively active AKT (AKT-CA) vector or constitutively active mitogen-activated protein kinase kinase 1 (MKK1-CA) vector increased the Rad52 protein level and cell survival, which were suppressed by NTG. | Nitroglycerin | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | The knockdown of Rad52 expression by using small interfering RNA or by inhibiting AKT and ERK1/2 activity enhanced the cytotoxicity and cell growth inhibition induced by NTG. | Nitroglycerin | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | Moreover, NTG synergistically enhanced the cytotoxicity and cell growth inhibition induced by pemetrexed in NSCLC cells; these effects were associated with AKT and ERK1/2 inactivation and, consequently, Rad52 downregulation in H520 and H1975 cells. | Nitroglycerin | AKT serine/threonine kinase 1 | Homo sapiens |