Title : Beta-Boswellic Acid Protects Against Cerebral Ischemia/Reperfusion Injury via the Protein Kinase C Epsilon/Nuclear Factor Erythroid 2-like 2/Heme Oxygenase-1 Pathway.

Pub. Date : 2022 Jul

PMID : 35505050






3 Functional Relationships(s)
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1 Additionally, beta-BA significantly increased the phosphorylation of protein kinase C epsilon (PRKCE) at S729, the translocation of nuclear factor erythroid 2-like 2 (NFE2L2), and expression of heme oxygenase-1 (HMOX1). boswellic acid NFE2 like bZIP transcription factor 2 Rattus norvegicus
2 Additionally, beta-BA significantly increased the phosphorylation of protein kinase C epsilon (PRKCE) at S729, the translocation of nuclear factor erythroid 2-like 2 (NFE2L2), and expression of heme oxygenase-1 (HMOX1). boswellic acid NFE2 like bZIP transcription factor 2 Rattus norvegicus
3 This study demonstrates that beta-BA exerts neuroprotective effects against cerebral I/R via the activation of the PRKCE/NFE2L2/HMOX1 pathway and is a potential therapeutic candidate for ischemic stroke. boswellic acid NFE2 like bZIP transcription factor 2 Rattus norvegicus