Title : Eugenol suppresses the proliferation and invasion of TNF-α-induced fibroblast-like synoviocytes via regulating NF-κB and COX-2.

Pub. Date : 2022 Jul 5

PMID : 35504091






3 Functional Relationships(s)
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1 Eugenol suppresses the proliferation and invasion of TNF-alpha-induced fibroblast-like synoviocytes via regulating NF-kappaB and COX-2. Eugenol mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Eugenol reversed the promoting effect of TNF-alpha on the expression of NF-kappaB signaling pathway-related proteins as well as prostaglandin-endoperoxide synthase 2 (PTGS2, also known as COX-2) protein. Eugenol mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 In conclusion, eugenol may represent a novel drug to suppress the progression of RA by inhibiting NF-kappaB signaling pathway and COX-2 expression in fibroblast-like synovial cells. Eugenol mitochondrially encoded cytochrome c oxidase II Homo sapiens